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dddd28.com 免疫调整怎样弃旧容新?以现时调整政策为基石,探索新式药物集合形式|2024 WCLC

dddd28.com 免疫调整怎样弃旧容新?以现时调整政策为基石,探索新式药物集合形式|2024 WCLC

*仅供医学专科东说念主士阅读参考dddd28.com

医学界带你看2024 WCLC

整理丨羊羊/言三语

备受肺癌鸿沟学者存眷的海外性学术嘉会——2024年天下肺癌大会(WCLC),将于当地时分9月7日至10日在好意思国圣地亚哥召开。近日,大会官网公布入选盘考(LBA暂未公布)。其中,看成肺癌鸿沟焦虑调整时代之一的免疫调整,比年来发展飞速,在本次大会中也诞生了多项免疫调整相干专题讲述。

医学界特此整理理论论述(Oral、Mini Oral)中部分免疫调整相干盘考,以飨读者。

改换免疫调整政策,新式免疫药物组合

纲要号:OA01.03

Association of Pathologic Regression with EFS in the KEYNOTE-671 Study of Perioperative Pembrolizumab for Early-Stage NSCLC

KEYNOTE-671盘录取病理驻守形式与帕博利珠单抗围手术期调整早期(NSCLC)无事件生计期(EFS)的关联

讲述巨匠:D.R. Jones 顾忌斯隆-凯特琳中心

纲要号:OA01.04

A Phase II Study of Perioperative Ivonescimab Alone or Combined with Chemotherapy in Resectable Non-Small Cell Lung Cancer

依沃西单抗(Ivonescimab,AK112)单药或集合化疗围手术期调整可切除NSCLC的II期盘考

讲述巨匠:赵晓亮 天津医科大学肿瘤病院

纲要号:OA06.03

SAFFRON-301: Tislelizumab Plus Sitravatinib in Advanced/Metastatic NSCLC Progressing on/after Chemotherapy and Anti-PD-(L)1

SAFFRON-301:替雷利珠单抗集合西妥昔单抗在化疗及抗PD-(L)1调整后/浮现的晚期/调感性NSCLC中的应用

讲述巨匠:吴一龙 广东省东说念主民病院

纲要号:OA06.04

Phase II Study of Pembrolizumab and Itacitinib for Patients with Metastatic NSCLC Expressing PD-L1: Long-Term Follow up

帕博利珠单抗集合Itacitinib调整PD-L1抒发的调感性NSCLC患者:一项II期盘考永恒随访

讲述巨匠:M.E. Marmarelis 宾夕法尼亚大学

纲要号:OA06.05

IL15 Superagonist (N-803, Anktiva) + Checkpoint Inhibi tor (CPI) Prolongs OS in 2ndline or Greater NSCLC Patients Failing CPI

IL15超振奋剂(N-803,吉吉色情Anktiva)+查验点阻难剂(CPI)延迟≥二线调整失败(包括CPI)的NSCLC患者的总生计期(OS)

讲述巨匠:J.Wrangle 南卡罗来纳医科大学

纲要号:OA11.03

Results of a Phase III Trial of Prolgolimab with Chemotherapy as First-Line Therapy for Patients with Advanced Non-Squamous NSCLC: DOMAJOR

清纯诱惑

III期DOMAJOR临床磨真金不怕火成果:Prolgolimab集合化疗看成晚期非鳞状NSCLC患者的一线调整有缱绻

讲述巨匠:D.Stroyakovsky 莫斯科市肿瘤病院

纲要号:MA01.05

Efficacy and Safety of Neoadjuvant Camrelizumab and Apatinib Combined with Chemotherapy in Stage IIIA (N2) NSCLC: A Single Arm, Phase II Trial

卡瑞利珠单抗+阿帕替尼集合化疗新扶助调整IIIA期(N2)NSCLC的疗效和安全性:单臂II期磨真金不怕火

讲述巨匠:L. Zhao 福建医科大学省立临床医学院

纲要号:MA16.04

Acasunlimab Alone or in Combination with Pembrolizumab for Previously Treated Metastatic Non-Small Cell Lung Cancer

Acasunlimab单药或集合帕博利珠单抗调整既往经治的调感性NSCLC

讲述巨匠:L. Paz-Ares Hospital 12 de Octubre

纲要号:MA16.06

KICKSTART: Tomivosertib Combined with Pembrolizumab in Previously Untreated PD-L1 High Stage IIIB/IV NSCLC

KICKSTART盘考:Tomivosertib集合帕博利珠单抗调整初治的PD-L1高抒发的IIIB/IV期NSCLC

讲述巨匠:S. Gadgeel 亨利福特肿瘤中 心

以现时免疫调整为基石,怎样弃旧容新?

纲要号:OA05.03

Ablation to Oligo-Residual Sites Plus ICIs Improved Survival of Patients with Advanced NSCLC: Preliminary Results of a Prospective Phase II Trial

寡残留部位消融集合免疫查验点阻难剂(ICI)可普及晚期NSCLC患者的生计率:一项前瞻性II期磨真金不怕火的初步成果

讲述巨匠:S. Yang 同济大学附庸上海市肺科病院

纲要号:OA05.06

Radiotherapy Combined with Enhanced Immunotherapy for NSCLC

放疗集合增强型免疫调整用于NSCLC

讲述巨匠:C. Miao 山东第一医科大学附庸肿瘤病院

纲要号:MA11.03

First-in-Class PD-1/IL-2 Bispecific Antibody IBI363 In Patients with Advanced Non-Small Cell Lung Cancer in a Phase I Study

First-in-Class的PD-1/IL-2双特异性抗体IBI363调整晚期NSCLC患者I期盘考

讲述巨匠:J. Zhou 浙江大学医学院附庸第一病院

纲要号:MA11.04

Nivolumab + Ipilimumab vs Chemotherapy in Patients with Stage IV/recurrent NSCLC and PD-L1 ≥ in China: Checkmate 227 CHESS

纳武利尤单抗+伊匹木单抗vs化疗调整IV期/复发性、PD-L1≥1%的NSCLC患者:Checkmate 227 CHESS盘考

讲述巨匠:吴一龙 广东省东说念主民医 院

纲要号:MA11.06

Pembrolizumab Plus Maintenance Olaparib as First-Line Therapy for Metastatic Nonsquamous NSCLC: Phase 3 KEYLYNK-006 Study

帕博利珠单抗集合奥拉帕利保管调整看成调感性非鳞状NSCLC的一线调整:III期KEYLYNK-006盘考

讲述巨匠:J.Gray 莫菲特癌症中心

纲要号:MA11.07

Preliminary Efficacy and Safety of SHR-1701 Plus Fluzoparib as Maintenance Therapy for Patients with Advanced Lung Squamous Cell Carcinoma

SHR-1701集合氟唑帕利看成晚期肺鳞状细胞癌患者保管调整的初步疗效和安全性

讲述巨匠:张永昌 湖南省肿瘤病院

纲要号:MA11.08

Phase II Trial of Atezolizumab Plus Cobimetinib in PD-(L)1 Inhibitor Resistant NSCLC: NCI ETCTN Study 10166

阿替利珠单抗集合Cobimetinib调整PD-(L)1阻难剂耐药的NSCLC患者:II期NCI ETCTN盘考10166

讲述巨匠:A. Saltos Moffitt Cancer Center,Tampa/FL/USA

纲要号:MA11.10

Benmelstobart,a PD-L1 Mab,Plus Anlotinib in EGFR+ Advanced NSCLC Patients Failed to Prior EGFR TKI Therapies:Phase II Results Update

贝莫苏拜单抗集合安罗替尼调整既往EGFR TKI调整失败的EGFR+晚期NSCL患者:II期盘考成果更新

讲述巨匠:史好意思祺 江苏省肿瘤病院

纲要号:MA11.11

A Phase Ib Study of TQB2618 (Anti-TIM-3) in Combination with Penpulimab and Chemotherapy in Patients with Non-Small Cell Lung Cancer

TQB2618(靶向TIM-3)集合派安普利单抗和化疗用于NSCLC患者的Ib期盘考

讲述巨匠:邬麟 湖南省肿瘤病院

纲要号:MA16.07

Survival Outcomes in Single Versus Double Immune Checkpoint Inhibitor in Advanced Non-Small Cell Lung Cancer: A Meta-Analysis

晚期NSCLC中ICI单药与双药调整的生计成果比拟:一项积存分析

讲述巨匠:B. Ponvilawan 密苏里大学

纲要号:MA16.09

Impact of Site of CAN-2409 Injection Plus Continued Immune Checkpoint Inhibitor(ICI)In CI-resistant stage III/IV NSCLC

CAN-2409打针部位以及ICI的握续使用对免疫调整后耐药的III/IV期NSCLC患者的影响

讲述巨匠:D. Sterman 纽约大学

探索肿瘤分子特点与免疫微环境

纲要号:MA01.11

Unveiling Gene Expression and Immune Contexture in Stage II/III NSCLC Patients Receiving Neoadjuvant Pembrolizumab and Chemotherapy

帕博利珠单抗集合化疗新扶助调整的II/III期NSCLC患者的基因抒发和免疫结构

讲述巨匠:陈玉龙 天津医科大学肿瘤病院

纲要号:MA07.11

AGRN-Positive Tumor Cells Promoting Immunotherapy Resistance in Lung Adenocarcinoma by Reshaping the Immune Microenvironment

AGRN阳性肿瘤细胞通过重塑免疫微环境促进肺腺癌的免疫调整叛逆

讲述巨匠:Z.Zhang四川省肿瘤临床医学盘录取心

纲要号:MA07.12

Unleashing the Potential of the Probiotic F.prausnitzii to Optimize PD-1 Inhibitor Efficacy in NSCLC Treatment

开释益生菌普拉梭菌优化NSCLC调整中PD-1阻难剂疗效的后劲

讲述巨匠:L. Jiang附庸胸科病院

纲要号:MA11.12

Peripheral T-Cell Receptor Repertoire Differentiates a Typical Progression in Non-Small Cell Lung Cancer Patients Treated with Immunotherapy

外周T细胞受体库鉴识接管免疫调整的NSCLC患者的典型浮现情况

讲述巨匠:J.Han 北京天坛病院

纲要号:MA16.03

Radiomic Biomarkers Predict Response to Immunotherapy Rechallenge in Recurrent NSCLC after Chemoradiation and Durvalumab

诓骗辐射组学生物符号物,掂量放化疗集合度伐利尤单抗调整后复发的NSCLC患者对免疫调整再引发的反馈

讲述巨匠:L. Delasos 克利夫兰诊所陶西格癌症中心

纲要号:MA16.10

PIEZO1+ Caner-associated Fibroblasts Shape an Inert Microenvironment to Suppress Anticancer Immunity in Non-Small Cell Lung Cancer

PIEZO1+癌症相干成纤维细胞塑造惰性微环境以阻难NSCLC中的抗癌免疫

讲述巨匠:M. Zhou 南边医科大学

纲要号:MA19.08

Transcriptomic Features of Circulating CX3CR1+CD8+ Temra Cells as a Predictor of Chemo-Immunotherapy Response in NSCLC Patients

轮回CX3CR1+CD8+ Temra细胞的转录组特征看成掂量NSCLC患者化疗集合免疫调整反馈的见地

讲述巨匠:J. Wu同济大学附庸上海市肺科病院

新式免疫调整组合在小细胞肺癌中的应用

纲要号:MA17.06

Durvalumab Plus Anlotinib Versus Durvalumab as Maintenance Treatment in ES-SCLC (DURABLE): A Randomized, Phase 2 Trial

比拟度伐利尤单抗集合安罗替尼与度伐利尤单抗单药保管调整芜俚期小细胞肺癌(ES-SCLC):一项速即的II期临床磨真金不怕火DURABLE

讲述巨匠:B.Han 上海交通大学附庸胸科病院

纲要号:MA17.07

Safety and Efficacy of Tifcemalimab Combined with Toripalimab in Refractory Extensive Stage Small Cell Lung Cancer

Tifcemalimab集合特瑞普利单抗调整难治性 ES-SCLC的安全性和灵验性

讲述巨匠:程颖 吉林省肿瘤病院

纲要号:MA17.08

Efficacy and Safety of Tislelizumab Plus Anlotinib and 2-Cycle Irinotecan as Second-Line Treatment for ES-Small Cell Lung Cancer(ESTAIL)

替雷利珠单抗集合安罗替尼和2周期伊立替康看成ES-SCLC二线调整的疗效和安全性(ESTAIL)

讲述巨匠:X. Chen广东省中病院

纲要号:MA17.10

NOTCH1 Expression Is Associated with Overall Survival in Small Cell Lung Cancer Patients Treated with Atezolizumab in IMpower133

IMpowe r133盘考:NOTCH1抒发与接管阿替利珠单抗调整的SCLC患者的OS相 关

讲述巨匠:N. Rope 好意思国国立癌症盘考所

纲要号:MA19.05

Dynamic Immune Profile of Peripheral Blood Predicts Immunotherapy Efficacy and Prognosis in Small Cell Lung Cancer

外周血动态免疫特征掂量SCLC患者免疫调整的疗效和预后

讲述巨匠:邬麟 湖南省肿瘤病院

备注:如有遗漏或任何问题,请给咱们留言。

更多WCLC精彩履行,敬请存眷医学界肿瘤频说念!

包袱剪辑:Sheep

*医学界勉力其发表履行专科、可靠,但不合履行的准确性作念出答允;请相干各方在罗致或以此看成决策依据时另行核查。



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